Single Dose of Intra-Muscular Platelet Rich Plasma as Therapeutic and Preventive Modalities in Exercise-Induced Muscle Damage

According to published work, platelet-rich plasma (PRP), an autologous derivative of whole blood containing a supraphysiological concentration of platelets, has gained increasing attention in both the scientific literature and the wider media for its potential application in the treatment of traumatic musculoskeletal injury and sports-related injuries. Related the our study results showed that acute exhaustive exercise increased muscle damage markers as a creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), including plasma iron, iron binding capacity (IBC), ferritin, hepcidin levels, indicating muscle damage induced by exercise.

However, PRP administration suppressed the increase the level of the iron, hepcidin and ferritin level due to muscle damage 2-3 days post-exercise. Evidently, we found that muscle strength peak torque values were improved after PRP compared to the control arm and this occurred on the same days (second and third day) when the serum iron and hepcidin level declined post exercise-induced muscle damage.

This result considered that PRP may be improved the muscle damage quickly. As an alternative to conventional treatments, platelet-rich therapy has been applied due to its potential in protecting iron stores and it may play a protective role exercise-induced anemia. However, it remains to be defined the effect of the intramuscular injection PRP on iron related parameters and hepcidin mechanism. In addition we found that 24 h following exercise increased levels of plasma insulin-like growth factor (IGF-1), growth hormone (GH) and insulin-like growth factor-binding protein 3 (IGFBP-3) in control were observed.

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