Erectile dysfunction (ED) remains one of the most frequent
disturbances of male health with great negative impact on psychological,
behavioral, and social conditions of the affected subject.
Moreover, a close correlation between ED and the risk of
cardiovascular diseases has recently become evident. The search for safe and
efficient approaches to combat and control ED has been growing steadily. Current
pharmacological means target two major causes of nonandrogen ED revealed so
far: the impaired signalling from central nervous system and/or peripherally
from penile tissue, to improve local endogenous metabolic pathways that control
the erection process.
The drugs/supplements inducing penile smooth muscle
relaxation are numerous, the best known being prostaglandin E1, NO donors,
phosphodiesterase inhibitors, bioactive peptides, excitatory amino acids, and
antagonists/agonists of neuro-transmitting and other receptors.
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