To determine the association between the c.+62G>A
and g.-420C>G polymorphisms and Type 2 Diabetes (T2D) or obesity
susceptibility for Mexicans. Additionally, we examined their overall effect
across different populations by a systematic review. Methods: 164 Mexicans were
classified as Healthy, Obese, or T2D. Genotypes were determined and associated
risk for the heterozygous, homozygous, dominant, recessive, and allelic
genetic models were determined by calculating the Odds Ratios (OR).
For the meta-analysis, original publications
that had determined RETN polymorphisms in T2D or obese subjects were searched
for in PubMed, Scopus, EBSCO, Ovid, and Wiley databases until November 2015,
using the search terms: T2D, obesity, RETN, and polymorphism. Pooled ORs were
computed using a random-effects or fixed-effects models.
Results: For our cohort, no associations were
observed between the polymorphisms and obesity or T2D. The metaanalysis
indicates an increased risk of obesity among carriers of the g.-420G allele for
the heterozygous and dominant models (OR=1.33 and OR=1.30, p<0.05,
respectively).
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