Friday 24 March 2017

Polymorphisms rs699 and rs4762 of the Angiotensinogen Gene and Progression of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Carotid Atherosclerosis

Cardiovascular and cerebrovascular diseases are leading causes of mortality in patients with diabetes mellitus. Beside diabetes mellitus, some of the traditional risk factors, such as hypertension, hypercholesterolaemia, smoking and positive family history, contribute as well to the high prevalence of cardiovascular disease in subjects with diabetes mellitus.

Ultrasound examination of carotid arteries enables visualization of different aspects of atherosclerosis. Beside carotid intima-media thickness (CIMT), which is the most studied non-invasive phenotype of carotid atherosclerosis, we can also measure plaque thickness, total plaque area, plaque volume, determine type of plaques, and degree of stenosis. CIMT is a good marker of early atherosclerosis and its progression

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