It is generally accepted that beside
cholesterol accumulation, chronic inflammation and immune system are very much
involved in the pathogenesis of atherosclerosis.
A genetic variability of the candidate genes
implicated in atherosclerosis (i.e. candidate genes of inflammation,
oxidative stress, growth factors, renin-angiotensin aldosterone system, and
so-forth) has so far been demonstrated in several reports to affect the
development of atherosclerosis.
Genetic variability in the candidate genes
implicated in atherosclerosis may alter their transcriptional activity and
contribute to susceptibility to cardiovascular disease. In the pathogenesis of
atherosclerosis genetic, environmental, and epigenetic factors are involved
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