Type 2 diabetes mellitus, a state
of hyperglycemia associated with beta cell dysfunction or insulin action on
target cells. This state is often mediated or sustained by obesity linked
inflammatrory cytokines.
Tumor necrosis factor-alpha
(TNF-α), most important inflammatory cytokine plays critical role in the pathogenesis
of type 2 diabetes mellitus as evidenced from higher circulating levels of
TNF-α in type 2 diabetes mellitus compared to controls and its negative
influence on insulin secretion and insulin sensitivity in type 2 diabetes
mellitus.
Positive association of TNF-α
with insulin secretion in subjects with impaired glucose regulation indicates
its causal relationship betacell dysfunction, insulin resistance or
sensitivity. In obese subjects with type 2 diabetes mellitus, we observed
stronger and graded relationship between TNF-α and obesity.
No comments:
Post a Comment