Thursday, 29 September 2016

Endoplasmic Reticulum Stress and Heart Complication in Diabetes

Diabetes and heart failure (HF) are closely related and often coexist. According to the Framingham Heart Study, the risk of HF was increased 2.4-fold in men and fivefold in women with diabetes. In another study of 10,000 patients, HF was more frequent in diabetic patients; 11.8% versus 4.5% in non-diabetic patients.

Complication in Diabetes
The HF is a complex syndrome resulting from functional and structural disorders that affect the capacity of the heart to fill or eject blood. Complications associated with Type 2 diabetes such obesity, lifestyle and hypertension are well known to contribute to the cardiovascular disease in diabetic patients. HF accounts for 33% of diabetic hospitalizations.

Evidence from clinical, experimental, and epidemiological studies has shown that diabetes mellitus causes cardiac dysfunction independently of hypertension, coronary artery disease or any other cardiac diseases, known as diabetic cardiomyopathy.

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