The oxidation of the B ring in steroidal compounds leads to
products exhibiting numerous biological functionalities. Ring B oxidized
sterols and steroids have shown anti-cancer activity.
7-Ketodehydroepiandrosterone has been shown to improve the
memory of mice and 3-acetyl-7-oxo-DHEA increases the resting metabolism of
persons on calorie restrictive diets. 7-Ketopregnenolone’s
has shown anti-cortisone properties.
7-Ketocholesterol has shown some regulatory function in the
biosynthesis of cholesterol. Furthermore, B ring oxidized steroidal compounds
may be used as synthetic reagents to make other steroidal products, such as a
steroidal pyrazoline.
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