Gestational diabetes mellitus (GDM) is a result of
carbohydrate intolerance which occurs during pregnancy. In one third of
patients, it returns to normal glucose tolerance after delivery. Alterations in
maternal
metabolism occur during normal pregnancy in order to provide the needs for
fetus and placenta and insulin secretion increases 2-2.5 fold to maintain the
euglycemic state.
A pregnancy accompanied by hyperinsulinemia represents a
causative factor for insulin resistance and leads to vascular dysfunction via
inflammatory mediators.
Insulin sensitivity also is decreased progressively owing to
the diabetogenic effects of gestational hormones and proinflammatory cytokines
have been attributed to be causative factors of insulin resistance
No comments:
Post a Comment