Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

It is generally accepted that beside cholesterol accumulation, chronic inflammation and immune system are very much involved in the pathogenesis of atherosclerosis.

A genetic variability of the candidate genes implicated in atherosclerosis (i.e. candidate genes of inflammation, oxidative stress, growth factors, renin-angiotensin aldosterone system, and so-forth) has so far been demonstrated in several reports to affect the development of atherosclerosis.

Genetic variability in the candidate genes implicated in atherosclerosis may alter their transcriptional activity and contribute to susceptibility to cardiovascular disease. In the pathogenesis of atherosclerosis genetic, environmental, and epigenetic factors are involved.

                                     
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