The ocular lens
of the ground squirrel is an excellent model for studies of eye light
interactions that may apply to the human system. UV-B radiation induced damage
to the eye lens is believed to be mediated through ROS Antioxidant systems,
both enzymatic and non- enzymatic aid in preventing the damage to the lens.
The activity of
indoleamine 2,3- dioxygenase (IDO), a first rate limiting enzyme of
tryptophan catabolism, has been studied in the lenses of Indian
ground squirrel exposed to UV-B radiation.
Further,
antioxidants and oxidative stress markers have also been investigated to assess
the oxidative status. Our investigation revealed an increased indoleamine
2,3-dioxygenase activity and tryptophan metabolites suggesting their protective
role in UV stress.
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