Melanoma is a
widespread cancer with poor prognosis. Female hormones are known to be capable
of influencing melanoma progression but clinical data related to pregnancy,
oral contraception and hormone replacement therapy are controversial.
A few reports
show that in vitro progesterone (PG) affects melanoma growth in nuclear
progesterone receptor (nPR)-positive and nPR-negative cells, but the
experimental protocols used are quite different and the results are not
univocal. Further research
on this topic is thus needed especially in view of the widespread use of PG in
clinical practice.
In this study, we
used human melanoma cells (A-375), which were cultured in vitro in the presence
or absence of a wide range of PG concentrations (from 0.01 to 1000 M) in single
treatment.
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