Changes in Antioxidant Enzymes in Metabolic Syndrome Patients after Consumption a Citrus-Based Juice Enriched with Aronia Melanocarpa

Increased oxidative stress has been suggested as an early event in the development of the metabolic syndrome and, as such, might contribute to disease progression.

The aim of de present study was to evaluate Total Antioxidant Status and endogenous antioxidant enzymes in metabolic syndrome patients after consumption of a citrus-based juice compared with control groups.

Before, and at sixth month after treatment the following parameters were determined: Total Antioxidant Status, Superoxide Dismutase, Glutathione Peroxidase and Glutathione Reductases.

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UV-B Exposure Increases the Activity of Indoleamine 2, 3-Dioxygenase

The ocular lens of the ground squirrel is an excellent model for studies of eye light interactions that may apply to the human system. UV-B radiation induced damage to the eye lens is believed to be mediated through ROS Antioxidant systems, both enzymatic and non- enzymatic aid in preventing the damage to the lens.

The activity of indoleamine 2,3- dioxygenase (IDO), a first rate limiting enzyme of tryptophan catabolism, has been studied in the lenses of Indian ground squirrel exposed to UV-B radiation.

Further, antioxidants and oxidative stress markers have also been investigated to assess the oxidative status. Our investigation revealed an increased indoleamine 2,3-dioxygenase activity and tryptophan metabolites suggesting their protective role in UV stress.

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