Sequential Contraction Compression Device Therapy affects Symptomatic Diabetic Peripheral Neuropathy

The authors evaluate a novel compression device, Sequential Contraction Compression Therapy Device (SCCD) on patients with hypo esthetic Diabetic Peripheral Neuropathy.

The authors selected 15 patients all of whom had a diagnosis of DPN and were currently taking 150 mg. of Pregabalin twice daily. After thirty days of treatment with SCCD, patients were evaluated for improvement in their pain score, amount of rescue drugs used, and the amount of sleep interference they experienced.

All patients experience statistically significant improvement in all three measurements.

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Pheochromocytoma: A Case Report and Literature Review

We present a case of pheochromocytoma with fatal paroxysmal dyspnea hemoptysis and shock. A systematic review of literature on pheochromocytoma was performed to improve the understanding of the clinical manifestation, diagnosis and treatment of a typical pheochromocytoma.

The clinical manifestation, diagnostic examination, operation mode and pathological characteristics of the typical pheochromocytoma, were analyzed and summarized. Simultaneously relevant literature was reviewed.

A 29-year-old male was diagnosed with pheochromocytoma with hemorrhagic cysts though without any typical clinical manifestation such as paroxysmal hypertension headache diaphoresis and palpitation.

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Pheochromocytoma: A Case Report and Literature Review

We present a case of pheochromocytoma with fatal paroxysmal dyspnea hemoptysis and shock. A systematic review of literature on pheochromocytoma was performed to improve the understanding of the clinical manifestation, diagnosis and treatment of a typical pheochromocytoma.

The clinical manifestation, diagnostic examination, operation mode and pathological characteristics of the typical pheochromocytoma, were analyzed and summarized. Simultaneously relevant literature was reviewed.

A 29-year-old male was diagnosed with pheochromocytoma with hemorrhagic cysts though without any typical clinical manifestation such as paroxysmal hypertension headache diaphoresis and palpitation.

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Analysis of BRAFV600E Mutation and Persistence of Papillary Thyroid Cancer after Total Thyroidectomy and Routine Central Neck Dissection

Purpose The aim of this study is to investigate the predictive value of BRAF V600E mutation for the persistence of papillary thyroid cancer (PTC) after total thyroidectomy and routine central neck dissection.

Patients and Methods We collect the clinicopathological data of 288 PTC patients with total thyroidectomy (TT) and routine central neck dissection (CND), and analyzed the relationship between BRAFV600E mutation status and the rate of elevated non-stimulated thyroglobulin (NSTg) value.

And we also collect the clinicopathological data of 370 PTC patients who needed radio iodine ablation(RIA) after TT and routine CND, and analyzed the relationship between BRAFV600E mutation status and the rate of elevated stimulated Tg (STg)value before RIA. independent predictive factor for the persistence of papillary thyroid cancer (PTC) after TT and routine CND.

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Current paradigms in the treatment of type 2 diabetes

Type 2 diabetes is an expanding epidemic worldwide, with recent data indicating at least 415 million adults with diabetes worldwide with an expected increase to 642 million by 2040 mainly in developing countries.

Multiple worldwide efforts are being undertaken to prevent diabetes by mitigating its risk factors– mainly obesity, reduced physical activity, increased consumption of salt, sugar and processed foods and reduced consumption of fruits and vegetables–yet these efforts are met with limited success. New approaches and medications to better improve the care of patients with established diabetes and reduce its resultant complications are being continuously developed, and these will be the focus of our current article.

Multiple studies have established the fact that early tight glycemic control reduces the risk of diabetes complications – microvascular, as well as macro vascular if initiated early in disease onset. Furthermore, addressing multiple cardiovascular risk factors, including lipids, blood pressure and anti-platelet therapy, has been shown to be crucial in the prevention of macro vascular complications.

Changing Our Mind: Beta Cell Workload Hypothesis

Despite recent advances in treatment options for type 2 diabetes (T2DM), the prevalence of T2DM continues to increase throughout the world. A healthy lifestyle is a key factor in both treatment and prevention of T2DM. A healthy lifestyle cannot be established without self-management ability.

T2DM is characterized by insulin resistance and beta cell dysfunction, which result in insufficient insulin action, leading to chronic hyperglycemia. However, since obesity is a major risk factor for T2DM, and hyperinsulinemia is also observed in individuals with T2DM, insulin resistance is often emphasized as a characteristic of T2DM. In contrast, since insulin resistance is considered to be accompanied by hyperinsulinemia, beta cell dysfunction is often ignored in these subjects.

However, recent studies showed that beta cell dysfunction, but not insulin resistance, is critical for the development of T2DM. Even in the obese subjects with T2DM, beta cell function and mass are reduced. These data suggest that beta cell dysfunction is the common pathogenetic feature of both type 1 and type 2 diabetes.

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Endoplasmic Reticulum Stress and Heart Complication in Diabetes

Diabetes and heart failure (HF) are closely related and often coexist. According to the Framingham Heart Study, the risk of HF was increased 2.4-fold in men and fivefold in women with diabetes. In another study of 10,000 patients, HF was more frequent in diabetic patients; 11.8% versus 4.5% in non-diabetic patients.

The HF is a complex syndrome resulting from functional and structural disorders that affect the capacity of the heart to fill or eject blood. Complications associated with Type 2 diabetes such obesity, lifestyle and hypertension are well known to contribute to the cardiovascular disease in diabetic patients. HF accounts for 33% of diabetic hospitalizations.

Evidence from clinical, experimental, and epidemiological studies has shown that diabetes mellitus causes cardiac dysfunction independently of hypertension, coronary artery disease or any other cardiac diseases, known as diabetic cardiomyopathy.

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